The Web Health | aspruzyo sprinkle Aspruzyo Sprinkle is a prescription heart failure medication designed for adults with reduced ejection fraction. It contains a combination of sacubitril and valsartan and works by improving blood flow and reducing strain on the heart. The unique sprinkle formulation allows for easy administration by mixing with soft food—ideal for those who have trouble swallowing pills. Aspruzyo Sprinkle should be taken exactly as prescribed by a healthcare provider for best results.