Ribociclib

Ribociclib is a targeted therapy used primarily to treat certain types of breast cancer, particularly hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. It is often used in combination with an aromatase inhibitor or endocrine therapy.

Mechanism
Ribociclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor. It works by blocking the activity of CDK4 and CDK6, which are proteins that help regulate the cell cycle. By inhibiting these kinases, ribociclib slows the growth and division of cancer cells.

Administration
Form: Taken orally as a tablet.

Dosage: Usually prescribed once daily for 21 days, followed by a 7-day break (28-day cycle).

Common side effects of ribociclib?

Common side effects of ribociclib may include:

Fatigue: Many patients feel unusually tired.

Nausea: Some may experience feelings of nausea or vomiting.

Diarrhea: Loose stools are a common problem.

Loss of appetite: A decrease in appetite may lead to weight loss.

Elevated liver enzymes: Elevated liver enzymes may be a sign of liver problems and require monitoring.

Neutropenia: Low levels of neutrophils, increasing the risk of infection.

Thinning of hair: Some patients may experience hair loss or thinning.

Headaches: Headaches may occur occasionally.

If you experience any side effects, especially if they are severe or persistent, it is important to talk to your healthcare provider for proper management.

Serious side effects of ribociclib?

Serious side effects of ribociclib may include:

Liver dysfunction: Significant elevations of liver enzymes (ALT and AST) may be a sign of liver damage, which requires close monitoring and discontinuation of the drug.

Severe neutropenia: A significant decrease in neutrophils may increase the risk of infection, which may be serious.

QT prolongation: Ribociclib may cause changes in heart rhythm, specifically prolongation of the QT interval, which may lead to serious heart problems.

Pulmonary embolism: There is a risk of blood clots forming in the lungs, which may be life-threatening.

Severe allergic reactions: Although rare, some patients may have severe allergic reactions, including anaphylaxis.

Hyperglycemia: Elevated blood sugar levels may occur, which requires monitoring and management.

If you experience any serious symptoms or changes in your health while taking ribociclib, it is important to seek medical help immediately.

Website: Ribociclib Price in Malaysia

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